--- title: Comprehensive Guide to Stem Cell Transplants in Chronic Myeloid Leukemia Treatment date: 2018-12-20T03:00:00-05:00 author: Courtney Flickinger canonical_url: "https://www.americordblood.com/articles/chronic-myelogenous-leukemia-and-stem-cell-treatments" section: Articles --- ![An image of a cell with purple spots, possibly indicating infection or mutation.](https://assets.americordblood.com/transforms/blogs/73382/myeloid-leukemia-cells-americord_dcd4b851eab0fdc82c7554dc6e8ca81c.png) [ Treatments & Clinical Trials ](https://www.americordblood.com/articles/treatments-clinical-trials) 2 Min Read # Comprehensive Guide to Stem Cell Transplants in Chronic Myeloid Leukemia Treatment ## Understanding Chronic Myeloid Leukemia (CML) Chronic Myeloid Leukemia (CML) is a subtype of leukemia distinguished by an overproduction of white blood cells, specifically granulocytes, in the bone marrow. This medical condition, often developing during or after an individual’s middle years, can also be found in children. What distinguishes CML from other types of leukemia is its slower progression. It primarily affects the bone marrow, which is the soft tissue responsible for creating blood cells. In CML, the bone marrow produces an excessive quantity of white blood cells, which eventually overcrowds the space meant for healthy blood cells. ## Inside the World of CML When someone is diagnosed with CML, their body is producing an excessive quantity of a specific type of white blood cell known as granulocytes. These granulocytes are not capable of maturing into healthy, fully functional white blood cells. As these unhealthy cells accumulate in the bone marrow, they begin to displace healthy white and red blood cells, as well as platelets. Consequently, individuals with CML may experience a higher susceptibility to infections, anemia (low red blood cell count), or have an increased tendency to bleed easily. These are significant complications as they directly impact the body’s immune response, oxygen transport, and blood clotting ability, respectively. ## The Role of Stem Cell Transplants in CML Treatment The primary treatment for CML involves eliminating the cancerous cells, which unfortunately also impacts the healthy stem cells within the bone marrow. Stem cell transplantation emerges as a crucial procedure following treatment, primarily to restore the bone marrow cells decimated by radiation or chemotherapy. The potential of stem cells to differentiate into bone marrow cells was demonstrated by Nobel Laureate E. Donnall Thomas in the 1970s, significantly contributing to our understanding of stem cell biology and its application in medicine. Stem cell transplantation has since become a cornerstone in the treatment of CML, offering a potential curative approach. ![An image of a smiling child with a teddy bear.](https://assets.americordblood.com/transforms/blogs/73383/chronic-myeloid-leukemia-treatment-americord_be7aaffd48750bec4e355d7110544d3f.png) ## Exploring the Potential of Cord Blood in CML Treatment While bone marrow transplants remain the most frequent method of stem cell transplantation in CML, cord blood transplants present a viable alternative. [Umbilical cord blood](https://www.americordblood.com/cord-blood) is rich in hematopoietic stem cells (HSCs), the same type of stem cells that make bone marrow transplants a potent treatment option. Stored cord blood offers a valuable resource as the HSCs it contains can potentially be used by the individual who stored them, or by a sibling with a similar condition. This versatility of cord blood stem cells opens up new avenues in the treatment of CML and other similar conditions. ### The Future is Bright In conclusion, stem cell transplantation, whether from bone marrow or cord blood, remains a crucial part of CML treatment. Advancements in stem cell biology and its applications are continuously broadening our understanding and treatment options for this condition. #### References: - [National Cancer Institute – Chronic Myelogenous Leukemia Treatment (PDQ®)–Health Professional Version ](http://www.cancer.gov/cancertopics/pdq/treatment/CML/HealthProfessional/page4) *The views, statements, and pricing expressed are deemed reliable as of the published date. Articles may not reflect current pricing, offerings, or recent innovations.* ### Cord Blood Banking Preserve your baby’s umbilical cord blood stem cells with CryoMaxx™ Processing and use in 80+ FDA-approved treatments and 100’s of clinical trials including autism, diabetes, childhood leukemia, sickle cell disease, and more. [ View Service ](https://www.americordblood.com/cord-blood) ### Be the First to Know Never miss the latest cord blood breakthrough, clinical trial, or stem cell education to keep your family healthy for life. 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[ Read More ](https://www.americordblood.com/articles/the-truth-about-stem-cells) [ ![A logo featuring red and orange circles, representing a vibrant and eye-catching design.](https://assets.americordblood.com/transforms/blogs/43737/where-stem-cells-come-from-americord_2023-10-17-154145_olwb_41a4f2ed037c5ad51696884668d44cc6.png) ](https://www.americordblood.com/articles/what-are-stem-cells) [### What are Stem Cells? ](https://www.americordblood.com/articles/what-are-stem-cells)Incredibly useful stem cells come from cord blood and tissue. Learn how we can safely collect and store your baby's stem cells. [ Read More ](https://www.americordblood.com/articles/what-are-stem-cells)