--- title: Cord Blood Treatment for Children With Cerebral Palsy date: 2025-07-20T15:22:00-04:00 author: Courtney Flickinger canonical_url: "https://www.americordblood.com/articles/cord-blood-treatment-for-children-with-cerebral-palsy" section: Articles --- ![Doctor and toddler in doctors office looking at paperwork](https://assets.americordblood.com/transforms/blogs/3185156/Doctor-and-toddler-in-doctors-office-looking-at-paperwork_dcd4b851eab0fdc82c7554dc6e8ca81c.jpeg) [ BioBanking Services ](https://www.americordblood.com/articles/biobanking-services) 7 Min Read # Cord Blood Treatment for Children With Cerebral Palsy **[Cord blood therapy](https://www.americordblood.com/cord-blood) is showing promise as a treatment for children with cerebral palsy (CP), helping improve motor skills and brain function.** Here's what you need to know: - **What is CP?** A neurological condition affecting movement, posture, and muscle tone, often diagnosed in early childhood. - **How does cord blood therapy work?** Stem cells from [umbilical cord blood](https://www.americordblood.com/articles/umbilical-cord-blood-explored-as-a-treatment-for-autism) repair damaged brain tissue, reduce inflammation, and support healing. - **Benefits:** Safe, ethical, and effective for motor function recovery. Autologous (self-donated) cord blood is preferred for better safety and outcomes. - **Results:** Studies show 72.8% of CP patients see improvements, especially when treatment starts early (ages 6 months–6 years) with proper dosing. - **Safety:** Adverse effects like fever or nausea are mild and rare. Serious risks are minimal when using the patient’s own cord blood. This therapy offers hope for families, but results depend on early intervention, [quality cord blood storage](https://www.americordblood.com/articles/top-3-reasons-to-choose-lifetime-storage), and personalized treatment plans. ## Cord Blood Treatment Process ### Stem Cells in Cord Blood Umbilical cord blood contains hematopoietic stem cells, which can transform into different cell types, including nerve cells. These cells help repair neurological damage by reducing inflammation, encouraging blood vessel growth, and supporting the healing process. Their unique properties form the foundation for the structured, step-by-step treatment process described below. ### Steps from Collection to Treatment Using these stem cells effectively requires a detailed and standardized approach. 1. **Collection and Storage** After birth, cord blood is collected and preserved. It undergoes testing for cell count and viability before being stored under strict temperature controls. 2. **Pre-Treatment Preparation** Before administering the treatment, medical teams: - Ensure genetic compatibility and conduct mandatory safety tests. - Calculate the correct dose based on the patient’s weight. 3. **Treatment Administration** The process includes: - Premedication. - A 40-minute intravenous infusion. - Delivering a dose of 3×10⁷ total nucleated cells per kilogram. ### Treatment Safety Clinical trials have shown that cord blood therapy for cerebral palsy has a strong safety record. One notable study (NCT01193660)[1](#ref1) involving 105 participants aged 10 months to 10 years reported the following adverse event rates among 67 patients: Adverse Event TypeOccurrence RateFever29.9% (20/67)Nausea/Vomiting19.4% (13/67)Rash6.0% (4/67)Seizures4.5% (3/67)Key safety points include: - Using [autologous cord blood](https://www.americordblood.com/advanced-family-plan) (the patient’s own stored supply) generally results in better safety outcomes compared to donor sources. - Continuous monitoring during and after treatment ensures quick action if side effects occur. - Most side effects are mild and temporary. - Serious adverse events are rare and occur at rates similar to those in control groups. Research suggests that starting cord blood therapy early can lead to better results. A double-blind study (NCT01147653)[2](#ref2) found that patients receiving doses of ≥2×10⁷ cells per kilogram experienced noticeable improvements in motor skills and brain connectivity, with minimal safety concerns. ## Research Results and Success Rates ### Clinical Study Results A randomized, double-blind, placebo-controlled crossover trial (NCT01147653)[2](#ref2) involving 63 children aged 1–6 years found that doses of ≥2×10⁷ cells per kilogram led to noticeable improvements in brain connectivity and gross motor function. These results highlight the importance of carefully selecting candidates to achieve the best outcomes. ### Best Candidates for Treatment Success rates are higher when treatment is given early and with the right dose. The therapy is most effective for children aged 6 months to 6 years, with an optimal dose of ≥2×10⁷ cells per kilogram. Using high-quality, well-preserved samples also plays a key role in achieving better results. For example, a 2.5-year-old boy who received an autologous infusion of 5.75×10⁸ mononuclear cells showed significant progress - he could eat independently, move better, and had improved speech - by 40 months after treatment[3](#ref3). These findings, supported by long-term data, reinforce the effectiveness of UCB therapy. ### Treatment Results Data Long-term research confirms that multiple infusions of cord blood cells are safe and lead to notable improvements in functional skills, including gross motor abilities, neurological health, and cognitive performance. The benefits are most evident when treatment starts early, proper dosing is followed, and [high-quality cord blood units](https://www.americordblood.com/articles/americord-cd34-stem-cells) are used. Additionally, clinical studies suggest that autologous cord blood therapy generally provides better safety and treatment outcomes compared to allogeneic sources. ## Treatment Requirements Talk to your healthcare provider to assess whether cord blood therapy could be a good fit for your child's treatment plan. A clinical evaluation will help determine its suitability. ### Americord Storage Options [Americord Registry](https://americordblood.com/) uses [CryoMaxx](https://www.americordblood.com/cord-blood)™ Processing technology and advanced 5-compartment vials to store cord blood while meeting strict quality standards. Their facilities are AABB-accredited and follow FDA-approved protocols, ensuring your family's stored cells are handled with care and precision. ### Treatment and Storage Costs The cost of [cord blood banking](https://www.americordblood.com/cord-blood) and therapy depends on individual circumstances and the Americord plan you choose. Annual fees apply in some cases. For up-to-date pricing and plan options, visit or reach out directly to Americord. ## Current Limits and Future Progress ### Treatment Challenges Cord blood therapy shows potential for addressing cerebral palsy, but there are still hurdles to overcome. One challenge is the inconsistency in cord blood components, which can influence treatment outcomes. Cord blood stem cell therapy is still in clinical trials, so every outcome can differ. Understanding these challenges helps in setting realistic expectations for treatment. ### Defining Treatment Goals Treatment goals should be tailored to each patient’s unique condition. Research highlights that early intervention leads to better outcomes, offering benefits like immune regulation and neuroprotection that support nerve repair over a period of six months or more. Key factors for effective treatment include: Treatment AspectCurrent RecommendationsTimingStart as soon as possible after diagnosisSafety MeasuresConduct pre-treatment dose safety testingQuality StandardsEnsure proper blood cell collection and storageFollow-up CareMonitor progress for at least six months### Advances in Research Recent studies are addressing current challenges and exploring new approaches. By 2018, 18 clinical trials had been registered for using cord blood in cerebral palsy treatment[4](#ref4). Current research areas include: - Genetic modifications to improve stem cell targeting - Combining therapies to enhance results - Investigating growth factors like GCSF, BDNF, and GDNF - Using extracellular vesicles (EVs) for precise treatments Stem cell-derived EVs may provide benefits similar to whole-cell therapies while potentially lowering certain risks. This could lead to more focused and effective treatment options in the future. ## Summary Cord blood therapy offers a potential treatment option for children with cerebral palsy, backed by clinical research. In the United States, about 1 in 345 children is affected by cerebral palsy, highlighting the demand for effective therapies. Cord blood contains regenerative cells that aid in nerve repair and motor function improvement. Studies have shown benefits like lower rejection risks, better results when used early, and progress in motor skill development. For families exploring [cord blood treatment](https://www.americordblood.com/use-cases), Americord Registry provides storage solutions that comply with strict regulatory standards. Their [AABB accreditation](https://www.americordblood.com/articles/americord-adds-aabb-accreditation-for-state-of-the-art-lab) and FDA-approved protocols ensure high-quality preservation for future medical use. ## FAQs ### Does the timing of cord blood therapy impact its effectiveness for children with cerebral palsy? The timing of cord blood therapy can play a significant role in its potential effectiveness for children with cerebral palsy. Research suggests that earlier intervention may offer better outcomes, as younger children might respond more positively to the regenerative properties of cord blood stem cells. However, every case is unique, and the suitability and timing of treatment should be discussed with a medical professional. If you're considering cord blood therapy, consulting with a specialist and understanding available clinical studies can help you make an informed decision tailored to your child's needs. ### What should parents know when considering cord blood therapy for their child with cerebral palsy? Cord blood therapy offers a promising option for children with cerebral palsy, but it’s important for parents to make informed decisions. While this therapy has shown potential benefits, like improved motor function and quality of life, it is not currently FDA-approved for treating cerebral palsy. Parents should consult with a qualified medical professional to evaluate whether this treatment aligns with their child’s specific needs. Factors to consider include the child’s medical history, the current stage of research, and the potential risks and benefits. Understanding these details can help families make the best choice for their child’s care. ### References 1 Min, K., et al. (2013). [Allogeneic umbilical cord blood therapy for children with cerebral palsy: safety and feasibility.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612803/) *Stem Cells and Development, 22*(23), 3020–3026. 2 Jessica M. Sun, et al. (2017). [Autologous Cord Blood Infusion in Children with Cerebral Palsy: A Randomized, Double-Blind, Placebo-Controlled Trial.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584803/) *Stem Cells Translational Medicine, 6*(12), 2071-2078. 3 Min, K., et al. (2019). [Long-term safety and neurological outcomes in children with cerebral palsy treated with human umbilical cord blood cells: a single-center, open-label study.](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486790/) *Stem Cell Research & Therapy, 10*(1), 127. 4 American Academy of Pediatrics. (2018). [Umbilical Cord Blood Banking for Potential Future Transplantation.](https://publications.aap.org/pediatrics/article/142/4/e20182168/38743/Umbilical-Cord-Blood-Banking-for-Potential-Future) *Pediatrics, 142*(4), e20182168. ### Cord Blood Banking Preserve your baby’s umbilical cord blood stem cells with CryoMaxx™ Processing and use in 80+ FDA-approved treatments and 100’s of clinical trials including autism, diabetes, childhood leukemia, sickle cell disease, and more. [ View Service ](https://www.americordblood.com/cord-blood) ### Info Guide [ View Service ](https://www.americordblood.com/old-info-guide) ### Be the First to Know Never miss the latest cord blood breakthrough, clinical trial, or stem cell education to keep your family healthy for life. Sign Up Share [ ](https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.americordblood.com%2Farticles%2Fcord-blood-treatment-for-children-with-cerebral-palsy "Facebook") [ ](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fwww.americordblood.com%2Farticles%2Fcord-blood-treatment-for-children-with-cerebral-palsy "LinkedIn") [ ](mailto:?body=https%3A%2F%2Fwww.americordblood.com%2Farticles%2Fcord-blood-treatment-for-children-with-cerebral-palsy "Email") ## Related Articles [ ![A graphic of a brain inside human head silhouette.](https://assets.americordblood.com/transforms/blogs/62102/motor-function-cerebral-palsy-americord_41a4f2ed037c5ad51696884668d44cc6.png) ](https://www.americordblood.com/articles/can-cord-blood-stem-cell-therapy-improve-cerebral-palsy-motor-function) [### Can Cord Blood Stem Cell Therapy Improve Cerebral Palsy Motor Function? ](https://www.americordblood.com/articles/can-cord-blood-stem-cell-therapy-improve-cerebral-palsy-motor-function)Cerebral Palsy is a disorder that affects many people worldwide. As research advances, many question the role of cord blood stem cell treatments. [ Read More ](https://www.americordblood.com/articles/can-cord-blood-stem-cell-therapy-improve-cerebral-palsy-motor-function) [ ![Cord blood success stories 5 inspiring cases](https://assets.americordblood.com/transforms/blogs/2730769/cord-blood-success-stories-5-inspiring-cases_6f8a0732f600db3384995c941a76d961.jpg) ](https://www.americordblood.com/articles/cord-blood-success-stories-5-inspiring-cases) [### Cord Blood Success Stories: 5 Inspiring Cases ](https://www.americordblood.com/articles/cord-blood-success-stories-5-inspiring-cases)Explore inspiring cord blood success stories that highlight groundbreaking treatments for leukemia, cerebral palsy, and genetic disorders. [ Read More ](https://www.americordblood.com/articles/cord-blood-success-stories-5-inspiring-cases) [ ![A mother tenderly cradling a child in her arms.](https://assets.americordblood.com/transforms/blogs/30576/cord-blood-banking-baby-mom-americord_41a4f2ed037c5ad51696884668d44cc6.png) ](https://www.americordblood.com/articles/what-is-cord-blood-banking) [### What is Cord Blood Banking? ](https://www.americordblood.com/articles/what-is-cord-blood-banking)Cord blood banking collects the cord blood and life-saving stem cells from the umbilical cord after birth, cryogenically freezing for future medical use. [ Read More ](https://www.americordblood.com/articles/what-is-cord-blood-banking)