Oct 17 2014

Why a Larger Cord Blood Collection is Better

Posted by Martin Smithmyer

Cord Blood 2.0 has officially been launched! This product was developed to help make cord blood a better and more viable treatment option, and after doing some thorough research, we found that the best way to accomplish this goal was to find a way to increase the size of cord blood collections.  We added the novel Gravity Stand to allow for gravity-assisted cord blood collections, and are now able to collect up to 2x the industry averages for volume of cord blood and number of stem cells collected.  A typical cord blood collection contains enough stem cells to treat patients weighing up to 65 pounds, so collecting more stem cells would expand treatment options as well as the number of patients eligible for transplants.  Below are some excerpts from reputable medical journals explaining why larger cord blood collections are better:

“The principal limitation of UCB is the finite and low number of stem cells present, which delay the time to HSC engraftment and prohibit further collection of stem cells or lymphocytes.  Many strategies to overcome this are currently being explored, and, if successful, may broaden the applicability of UCB transplantation yet further.” -Practical Transfusion Medicine, February 2013

“A major limitation to the use of cord-blood grafts in adults is the concern that these grafts have an insufficient number of precursor cells as compared with bone-marrow grafts.  Reports of cord-blood transplantation in adults suggest that hematopoietic recovery is faster with higher cell doses.” -The New England Journal of Medicine, November 2004

“Graft cell dose is an important determinant  of hematopoietic recovery and overall outcome following UCB transplantation, and the limited cell dose of single UCB units has been a major barrier to its more widespread use.” -Current Opinion in Immunology, August 2006

“The major disadvantage of cord blood stem cells concerns what is called cell dose.  The number of stem cells in a typical cord blood donation is about one tenth of what is obtained from an adult bone marrow donor.  Thus, cord blood from single donors is generally limited to treating small children.” -Pediatrics for Parents, June 2009

“A major factor that limits the use of cord blood is the number of nucleated cells and CD34+ cells in the graft.  There is a consensus that a unit of cord blood should have at least 2.0 x 10^7 nucleated cells per kilogram at the time of freezing and no more than two disparities in the matching for HLA-A, B, or DRB1, alone or in combination, with the recipient.” -The New England Journal of Medicine, November 2004

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