A placenta on a table with some surgical tools.

What is Placental Tissue 2.0™ Processing?

Americord’s unique proprietary Placental Tissue 2.0™ processing method uses a minimal manipulation method to isolate the amnion layer of the placental tissue to retain its inherent multipotent cells, growth factors, and cytokines. 

The amnion tissue is cryopreserved and stored in multiple vials, ensuring the potential for multiple uses for your baby, siblings, parents, or grandparents. This processing method creates a versatile tissue and gives families the flexibility to use:

  • Amniotic epithelial cells and amniotic mesenchymal stem cells for therapeutic applications.
  • Amniotic tissue containing multi-potent cells, growth factors and cytokines for wound and ocular applications.

What is the Placenta?

The placenta is a disc-shaped organ that develops during pregnancy and is attached to the wall of the uterus. It connects to the baby via the umbilical cord which delivers oxygen and nutrients to the baby and removes waste products from the baby. 

The placenta holds an important role during pregnancy. It acts as a barrier to bacteria and viruses to protect the baby. It also produces hormones and signaling molecules that help the baby grow. 

Did you know? In a study characterizing the placenta, researchers determined that the placenta contains 65% of all the proteins found in the entire human body, which includes growth factors and cytokines. 

The placental membrane consists of an amnion layer and a chorion layer. The amnion is baby facing and the chorion is maternal facing.

The placental membrane, specifically the amnion layer, has been used for more than a century to successfully treat wounds and burns.¹⁻³ The first known application was at Johns Hopkins Hospital in 1910. 

As researchers have studied placental membranes in more depth, they have learned that each part of the placental membrane plays a significant role in regenerative medicine. The key elements of placental membranes include:⁵  

  • Amniotic Epithelial Cells (AECs): Present on the top-most layer of amnion and can differentiate into various types of cells and tissue types.⁶
  • Amniotic Mesenchymal Stem Cells (AMSCs): Multi-potent stem cells capable of differentiating into a number of different cell and tissue types.⁷
  • Growth Factors: Signaling molecules that regulate cell growth and tissue regeneration.
  • Cytokines: Signaling molecules that regulate inflammation.
  • Extracellular Matrix (ECM): A three-dimensional structure consisting of various collagens and proteins that directs cellular behavior such as differentiation, proliferation, and signaling.

What Clinical Research is Being Conducted on Placental Tissues?

Amniotic epithelial cells and amniotic mesenchymal stem cells are currently being studied for:⁸⁻⁹

  • Autoimmune diseases
  • Cancer
  • Graft vs Host disease
  • Gynecological conditions
  • Lung diseases
  • Neurological disorders
  • Orthopedic conditions

Placenta tissue containing multi-potent cells, growth factors, cytokines, and ECM is being studied in a number of clinical trials. The amnion layer was specifically chose by scientists because it has a structure that is similar to that of skin and ocular surfaces:¹⁰⁻¹⁶

  • Chronic Venous Leg Ulcers
  • Corneal Healing
  • Diabetic Foot Ulcers
  • Dry Eye
  • Knee Osteoarthritis
  • Pressure Ulcers
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